2-Methoxyestradiol 362-07-2 CAS NO.362-07-2 CAS NO.362-07-2

Name: 2-Methoxyestradiol 362-07-2 CAS NO.362-07-2
SKU: 362-07-2
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Name:: Estra-1,3,5(10)-triene-3,17-diol,2-methoxy-, (17b)- (Related Reference)
Molecular Formula:: C₁₉H₂₆O₃
CAS Registry Number:: 362-07-2
Synonyms:: Estra-1,3,5(10)-triene-3,17b-diol, 2-methoxy- (7CI,8CI); Estradiol, 2-methoxy- (6CI); 2-Hydroxyestradiol 2-methyl ether; 2-Methoxyestra-1,3,5(10)-triene-3,17b-diol; NSC 659853; Panzem;
InChI:: InChI=1/C19H26O3/c1-19-8-7-12-13(15(19)5-6-18(19)21)4-3-11-9-16(20)17(22-2)10-14(11)12/h9-10,12-13,15,18,20-21H,3-8H2,1-2H3/t12-,13+,15-,18-,19-/m0/s1
Molecular Structure:
: This structure is also available as a 2d Mol file

Appearance:: Off-white solid
Molecular Weight:: 302.41
Density:: 1.178g/cm³
Boiling Point:: 464.4°Cat760mmHg
Melting Point:: 188-190°C
Flash Point:: 234.7°C
Storage Temperature:: −20°C
Refractive index:: 1.586
Solubility:: DMSO: 10 mg/mL
Biological Activity:: Apoptotic, antiproliferative and antiangiogenic agent, in vitro and in vivo ; acts via an estrogen receptor-independent mechanism. Induces p53-induced apoptosis via two pathways: activation of p38 and NF- κ B; and activation of JNK and AP-1 leading to Bcl-2 phosphorylation. Also upregulates death receptor 5 and binds to tubulin, inhibiting its assembly.
Usage:: 2-Methoxyestradiol (CAS.362-07-2) is a natural metabolite which is devoid of estrogenic activity. It is inhibits cell proliferation and angiogenesis.